ChIP-seq

Chromatin Immunoprecipitation Sequencing (ChIP-seq) is a method to identify protein binding to DNA. The data is typically processed into peaks which indicate which regions of a reference genome are bound to the proteins of interest.

The central limitation of ChIP-seq is that only 1 protein of interest can be studied at a time. This means that it is prohibitively expensive to do ChIP-seq on every protein in a cell for a given condition.

This method is very similar in output (but not methodology) to techniques like CUT&RUN and CUT&TAG.